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Psychedelic Drug an overview Their highest density is found in limbic regions of the brain such as the hippocampus (Hamon et al., 1990), areas where emotion and affect would be modified by agonist and antagonist drug interactions. Autoradiographic studies demonstrated the presence of 5-HT1A receptors in layer V of the rat PFC (Glaser et al., 1985; Pazos and Palacios, 1985), and neurons in the human neocortex contain mRNA for the 5-HT1A receptor, with pyramidal cells in layer III more heavily labeled than those in layer V (Burnet et al., 1995). González-Maeso et al. then compared effects on in vivo gene expression of three agonists evaluated in the HTR. Transcript levels in the mouse somatosensory cortex 1 hour after agonist injection were compared by quantitative reverse-transcription polymerase chain reaction to those from vehicle-injected controls. Thirteen transcripts showed significant changes after at least one agonist, with each agonist showing a unique and reproducible transcr